Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells
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چکیده
منابع مشابه
Effects of Cadmium on Cellular and Subcellular Structures of Cerebellar Purkinje Cells in Four-Day Postnatal Developing Rat
Purpose: This experiment was conducted to evaluate the effects of Cd on cellular and subcellular aspects of cerebellar Purkinje cells in developing rats. Materials and methods: forty adult female Wistar rats served as subjects in this experiment. The animals were assigned randomly to four groups: control I, control II, experiment I and experiment II. The experiment group I and II were injected...
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The leaner (tg(la)) mouse mutation occurs in the gene encoding the voltage-activated Ca(2+) channel alpha(1A) subunit, the pore-forming subunit of P/Q-type Ca(2+) channels. This mutation results in dramatic reductions in P-type Ca(2+) channel function in cerebellar Purkinje neurons of tg(la)/tg(la) mice that could affect intracellular Ca(2+) signaling. We combined whole cell patch-clamp electro...
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Purkinje neurons play an important role in cerebellar computation since their axons are the only projection from the cerebellar cortex to deeper cerebellar structures. They have complex internal dynamics, which allow them to fire spontaneously, display bistability, and also to be involved in network phenomena such as high frequency oscillations and travelling waves. Purkinje cells exhibit type ...
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Cerebellar Purkinje cells are known to receive strong excitatory input from two major pathways originating outside the cerebellum and inhibitory input from two types of neurons in the cerebellar cortex. The functions and synaptic strengths of these pathways are only partially known. We have used the patch-clamp technique applied to Purkinje cells in thin slices of rat cerebellum to measure dire...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-38730-4